I look back on where I found all my success, and it didn't come from sitting behind a computer screen. It came from talking on the phone with a live person, or meeting people in person. It came from going to networking groups, Chamber of Commerce mixers, and just venturing outdoors and seeing what happens.
Once you make a connection with someone live, then you can rely on Twitter to stay in communication, but you will never get anywhere trying to meet clients on Twitter.
I'm just an average web guy, with poor design skills. My knowledge of programming is pretty limited to just HTML and basic CSS. I know how to make websites, and make them look half-way decent. Otherwise, all my success being self-employed came via person-to-person skills.
You just gotta get out of the house and meet people, if you ever want to get anywhere.
At least, that's what my mom always told me. And, it seems she was right. ✓